Indication
Migranal® (dihydroergotamine mesylate, USP) Nasal Spray is used to treat an active migraine headache with or without aura. Do not use it to try to prevent a migraine if you have no symptoms, to treat a common tension headache, or to treat a migraine that is not typical of your usual migraine.
Important Safety Information
Serious or potentially life-threatening reductions in blood flow to the brain or extremities due to interactions between dihydroergotamine (the active ingredient in Migranal Nasal Spray) and protease inhibitors and macrolide antibiotics have been reported rarely. As a result, these medications should not be taken together.
Do not use Migranal Nasal Spray if you:
- Are taking certain anti-HIV medications known as protease inhibitors
- Are taking a macrolide antibiotic such as troleandomycin, clarithromycin, or erythromycin
- Are pregnant or nursing
- Have any disease affecting your heart, arteries, or blood circulation
- Have taken other medications for the treatment or prevention of migraine within the last 24 hours
- Have severe liver or kidney disease
- Experience hemiplegic or basilar migraines, which often cause paralysis or impairment of speech
The use of Migranal Nasal Spray should not exceed dosing guidelines and should not be used on a daily basis.
Serious cardiac (heart) events, including some that have been fatal, have occurred following use of injectable dihydroergotamine, the active ingredient in Migranal Nasal Spray, but are extremely rare.
You may experience some nasal congestion or irritation, altered sense of taste, sore throat, nausea, vomiting, dizziness, and fatigue after using Migranal Nasal Spray.
Please see accompanying full Prescribing Information including Boxed Warning and Patient Information.
You are encouraged to report adverse side effects of prescription drugs to the FDA. Visit
www.fda.gov/medwatch or call 1-800-FDA-1088.