MIGRANAL is delivered through a compact and portable nasal spray. Nasal sprays provide several benefits; a nasal spray:
Administration Instructions: How to Use MIGRANAL Nasal Spray1
Important: Do not assemble the nasal spray pump until the time of use. Once it has been opened, it must be discarded after 8 hours.
Lift tab to bend back blue cover (Figure 1). In one piece, completely remove the blue cover and metal seal in a circular motion (Figure 2). Keeping the vial upright, remove the rubber stopper (Figure 3). Set vial aside.
Remove plastic cover from bottom of pump unit (Figure 4). Insert spray pump into vial and turn clockwise until securely fastened (Figure 5).
Remove cap from spray unit (Figure 6). Holding the vial as shown in Figure 7, point the nasal sprayer away from face and pump 4 times before using (Figure 7). DO NOT PUMP MORE THAN 4 TIMES. (Although some medication will spray out, there is enough medication in each vial to allow you to prepare your nasal spray pump properly and still receive a full treatment of MIGRANAL.)
Spray once into each nostril (Figure 8). Do not tilt head back or sniff through your nose while spraying or immediately after. Wait 15 minutes. Spray once again into each nostril.
After completing these instructions, carefully dispose of the nasal spray pump with vial.
Migranal® (dihydroergotamine mesylate, USP) Nasal Spray is used to treat an active migraine headache with or without aura. Do not use it to try to prevent a migraine if you have no symptoms, to treat a common tension headache, or to treat a migraine that is not typical of your usual migraine.
Serious or potentially life-threatening reductions in blood flow to the brain or extremities due to interactions between dihydroergotamine (the active ingredient in Migranal Nasal Spray) and protease inhibitors and macrolide antibiotics have been reported rarely. As a result, these medications should not be taken together.
The use of Migranal Nasal Spray should not exceed dosing guidelines and should not be used on a daily basis.
Serious cardiac (heart) events, including some that have been fatal, have occurred following use of injectable dihydroergotamine, the active ingredient in Migranal Nasal Spray, but are extremely rare.
You may experience some nasal congestion or irritation, altered sense of taste, sore throat, nausea, vomiting, dizziness, and fatigue after using Migranal Nasal Spray. Contact your doctor immediately if you experience: