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Proven to Provide Rapid and Long-Lasting Migraine Relief

In clinical studies…


Some MIGRANAL patients felt relief within 30 minutes of use1


compared with <10% for placebo


About half of MIGRANAL patients experienced migraine relief within 2 hours1,2


compared with 23% for placebo*


More than half of MIGRANAL patients had less need for other pain relievers for 24 hours1,2


compared with 67% for placebo

Nausea and sensitivity to light and sound were reduced at 2 and 4 hours after taking MIGRANAL.1,2

*In a second study, 47% of MIGRANAL patients and 33% of placebo-treated patients experienced migraine relief within 2 hours.2

MIGRANAL Is a Different Type of Migraine Medicine

MIGRANAL is a nasal spray for the treatment of migraine headaches with or without aura and
works differently than other commonly prescribed migraine treatments.1-5

1 in 3

migraine patients does not get relief with his or her current migraine medicine.3 Are you getting relief from your migraines? If not, talk to your doctor about making a move to MIGRANAL.


MIGRANAL: Because Mygraine Is Different

Do any of the following apply to you?

Wake up with migraines1-3
Unable to take an oral migraine medicine due to nausea or vomiting1-3
Delay using your migraine medicine until the pain is severe1-3,6
Find your current migraine medicine isn’t working well1-3,6
Experience an aura prior to migraines2
Have no warning signs about when a migraine attack is about to happen2

If you answered “yes” to any of the above, MIGRANAL may be the right migraine medicine for you.

MIGRANAL Was Generally Well-Tolerated

Studies have shown that most people used MIGRANAL without serious side effects. You may experience some nasal congestion or irritation, altered sense of taste, sore throat, nausea, vomiting, dizziness, or extreme tiredness after using MIGRANAL. These side effects are temporary and usually do not require you to stop using MIGRANAL.2

Rare, but serious reactions can occur, and should be reported immediately to your doctor2:

  • Numbness or tingling in your fingers or toes
  • Pain, tightness, or discomfort in your chest
  • Muscle pain or cramps in your arms and legs
  • Weakness in your legs
  • Temporary speeding or slowing of your heart rate
  • Swelling or itching
  1. Gallagher RM; Dihydroergotamine Working Group. Acute treatment of migraine with dihydroergotamine nasal spray. Arch Neurol. 1996;53(12):1285-1291.
  2. MIGRANAL [package insert]. Bridgewater, NJ: Valeant Pharmaceuticals North America.
  3. Baron EP, Tepper SJ. Revisiting the role of ergots in the treatment of migraine and headache. Headache. 2010;50(8):1353-1361.
  4. Viana M, Genazzani AA, Terrazzino S, Nappi G, Goadsby PJ. Triptan nonresponders: do they exist and who are they? Cephalalgia. 2013;33(11):891-896.
  5. Levy D, Jakubowski M, Burstein R. Disruption of communication between peripheral and central trigeminovascular neurons mediates the antimigraine action of 5HT1B/1D receptor agonists. Proc Natl Acad Sci U S A. 2004;101(12):4274-4279.
  6. Silberstein S. Practice parameter: evidence-based guidelines for migraine headache (an evidence-based review): report of the Quality Standards Subcommittee of the American Academy of Neurology. Neurology. 2000;55(6):754-762.

Migranal® (dihydroergotamine mesylate, USP) Nasal Spray is used to treat an active migraine headache with or without aura. Do not use it to try to prevent a migraine if you have no symptoms, to treat a common tension headache, or to treat a migraine that is not typical of your usual migraine.



Serious or potentially life-threatening reductions in blood flow to the brain or extremities due to interactions between dihydroergotamine (the active ingredient in Migranal Nasal Spray) and protease inhibitors and macrolide antibiotics have been reported rarely. As a result, these medications should not be taken together.

Do not use Migranal Nasal Spray if you:
  • Are pregnant or nursing
  • Have any disease affecting your heart, arteries, or blood circulation
  • Are taking certain anti-HIV medications known as protease inhibitors
  • Are taking a macrolide antibiotic such as troleandomycin, clarithromycin, or erythromycin
  • Have taken other medications for the treatment or prevention of migraine within the last 24 hours
  • Have severe liver or kidney disease
  • Experience hemiplegic or basilar migraines, which often cause paralysis or impairment of speech
Before taking Migranal Nasal Spray, tell your doctor if:
  • You have high blood pressure, chest pain, shortness of breath, heart disease; or risk factors for heart disease (such as high blood pressure, high cholesterol, obesity, diabetes, smoking, strong family history of heart disease or you are postmenopausal, or male over 40); or problems with blood circulation in your arms, legs, fingers, or toes
  • You are pregnant, planning to become pregnant or are nursing, or have ever stopped medication due to an allergy or bad reaction
  • You are taking any prescription or over-the-counter medications, including vitamins or herbal supplements
  • You have or had any disease of the liver or kidney
  • This headache is different from your usual migraine attacks

The use of Migranal Nasal Spray should not exceed dosing guidelines and should not be used on a daily basis.

Serious cardiac (heart) events, including some that have been fatal, have occurred following use of injectable dihydroergotamine, the active ingredient in Migranal Nasal Spray, but are extremely rare.

You may experience some nasal congestion or irritation, altered sense of taste, sore throat, nausea, vomiting, dizziness, and fatigue after using Migranal Nasal Spray. Contact your doctor immediately if you experience:

  • Numbness or tingling in your fingers and toes
  • Pain, tightness, or discomfort in your chest
  • Muscle pain or cramps in your arms and legs
  • Weakness in your legs
  • Temporary speeding or slowing of your heart rate
  • Swelling or itching

You are encouraged to report adverse side effects of prescription drugs to the FDA. Visit or call 1-800-FDA-1088.

Please click here for full Prescribing Information, including Boxed Warning and Patient Information.