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MIGRANAL:
Proven to Provide Rapid and Long-Lasting Migraine Relief

In clinical studies…

 

Some MIGRANAL patients felt relief within 30 minutes of use1

27%

compared with <10% for placebo

 

About half of MIGRANAL patients experienced migraine relief within 2 hours1,2

61%

compared with 23% for placebo

 

More than half of MIGRANAL patients had less need for other pain relievers for 24 hours1,2

86%

compared with 67% for placebo

Nausea and sensitivity to light and sound were reduced at 2 and 4 hours after taking MIGRANAL.1,2

MIGRANAL Is a Different Type of Migraine Medicine

MIGRANAL is a nasal spray for the treatment of migraine headaches with or without aura and
works differently than other commonly prescribed migraine treatments.1-5

MIGRANAL works differently

There are 2 phases of migraine, an early and late phase.6 During the early phase of migraine, people feel the common symptoms of migraine such as throbbing pain, nausea, and sensitivity to light and sound.2,5,7-9 If migraine medicine is not taken at this time, the migraine can progress to a later phase. This phase includes more severe pain and makes the migraine more difficult to treat.5-7,9

Many commonly prescribed migraine medications only work during the early phase of migraine.10 The active ingredient in MIGRANAL may target early AND late phases.2,7

1 in 3

migraine patients do not get relief with their current migraine medicine.3 Are you getting relief from your migraines? If not, talk to your doctor about making a move to MIGRANAL.

 

MIGRANAL Was Generally Well-Tolerated

Studies have shown that most people used MIGRANAL without serious side effects. You may experience some nasal congestion or irritation, altered sense of taste, sore throat, nausea, vomiting, dizziness, or extreme tiredness after using MIGRANAL. These side effects are temporary and usually do not require you to stop using MIGRANAL.2

Rare, but serious reactions can occur, and should be reported immediately to your doctor2:

  • Numbness or tingling in your fingers or toes
  • Pain, tightness, or discomfort in your chest
  • Muscle pain or cramps in your arms and legs
  • Weakness in your legs
  • Temporary speeding or slowing of your heart rate
  • Swelling or itching
References:
  1. Gallagher RM; Dihydroergotamine Working Group. Acute treatment of migraine with dihydroergotamine nasal spray. Arch Neurol. 1996;53(12):1285-1291.
  2. MIGRANAL [package insert]. Bridgewater, NJ: Bausch Health Companies Inc.
  3. Baron EP, Tepper SJ. Revisiting the role of ergots in the treatment of migraine and headache. Headache. 2010;50(8):1353-1361.
  4. Viana M, Genazzani AA, Terrazzino S, Nappi G, Goadsby PJ. Triptan nonresponders: do they exist and who are they? Cephalalgia. 2013;33(11):891-896.
  5. Levy D, Jakubowski M, Burstein R. Disruption of communication between peripheral and central trigeminovascular neurons mediates the antimigraine action of 5HT1B/1D receptor agonists. Proc Natl Acad Sci U S A. 2004;101(12):4274-4279.
  6. Burstein R, Jakubowski M, Rauch SD. The science of migraine. J Vestib Res. 2011;21(6):305-314.
  7. Masterson CG, Durham PL. DHE repression of ATP-mediated sensitization of trigeminal ganglion neurons. Headache. 2010;50(9):1424-1439.
  8. Noseda R, Burstein R. Migraine pathophysiology: anatomy of the trigeminovascular pathway and associated neurological symptoms, CSD, sensitization and modulation of pain. Pain. 2013;154(suppl 1).
  9. Kelley NE, Tepper DE. Rescue therapy for acute migraine, part 1: triptans, dihydroergotamine, and magnesium. Headache. 2012;52(1):114-128.
  10. Burstein R, Cutrer MF, Yarnitsky D. The development of cutaneous allodynia during a migraine attack: clinical evidence for the sequential recruitment of spinal and supraspinal nociceptive neurons in migraine. Brain. 2000;123(Pt 8):1703-1709
INDICATION

MIGRANAL® (dihydroergotamine mesylate) Nasal Spray is used to treat an active migraine headache with or without aura. Do not use it to try to prevent a migraine if you have no symptoms, to treat a common tension headache, or to treat a migraine that is not typical of your usual migraine.

IMPORTANT SAFETY INFORMATION

Serious or potentially life-threatening reductions in blood flow to the brain or extremities due to interactions between dihydroergotamine (the active ingredient in MIGRANAL Nasal Spray) and protease inhibitors and macrolide antibiotics have been reported rarely. As a result, these medications should not be taken together.

Do not use MIGRANAL Nasal Spray if you:
  • Are pregnant or nursing
  • Have any disease affecting your heart, arteries, or blood circulation
  • Are taking certain anti-HIV medications known as protease inhibitors
  • Are taking a macrolide antibiotic such as troleandomycin, clarithromycin, or erythromycin
  • Have taken other medications for the treatment or prevention of migraine within the last 24 hours
  • Have severe liver or kidney disease
  • Experience hemiplegic or basilar migraines, which often cause paralysis or impairment of speech
Before taking MIGRANAL Nasal Spray, tell your doctor if:
  • You have high blood pressure, chest pain, shortness of breath, heart disease; or risk factors for heart disease (such as high blood pressure, high cholesterol, obesity, diabetes, smoking, strong family history of heart disease or you are postmenopausal, or male over 40); or problems with blood circulation in your arms, legs, fingers, or toes
  • You are pregnant, planning to become pregnant or are nursing, or have ever stopped medication due to an allergy or bad reaction
  • You are taking any prescription or over-the-counter medications, including vitamins or herbal supplements
  • You have or had any disease of the liver or kidney
  • This headache is different from your usual migraine attacks

The use of MIGRANAL Nasal Spray should not exceed dosing guidelines and should not be used on a daily basis.

Serious cardiac (heart) events, including some that have been fatal, have occurred following use of injectable dihydroergotamine, the active ingredient in MIGRANAL Nasal Spray, but are extremely rare.

You may experience some nasal congestion or irritation, altered sense of taste, sore throat, nausea, vomiting, dizziness, and fatigue after using MIGRANAL Nasal Spray. Contact your doctor immediately if you experience:

  • Numbness or tingling in your fingers and toes
  • Pain, tightness, or discomfort in your chest
  • Muscle pain or cramps in your arms and legs
  • Weakness in your legs
  • Temporary speeding or slowing of your heart rate
  • Swelling or itching

You are encouraged to report adverse side effects of prescription drugs to Bausch Health US, LLC at 1-800-321-4576 or the FDA. Visit www.fda.gov/medwatch or call 1-800-FDA-1088.

Please click here for full Prescribing Information, including Boxed Warning and Patient Information.